Sepsis is a life‑threatening organ dysfunction caused by the host's unbalanced response to infection. Septic cardiomyopathy is a common complication of sepsis. As the main organoid of energy supply for cardiomyocytes, the abnormal structure and dysfunction of mitochondria plays an important role in septic cardiomyopathy. This review aims to summarize the relevant mechanisms of mitochondrial dysfunction which causes myocardial injury in sepsis, including: reactive oxygen species produced and oxidative stress occurred in mitochondria , disorder energy metabolism of mitochondria, imbalanced mitochondrial dynamics, abnormal mitochondrial biosynthesis and autophagy process for providing new ideas to help the clinical treatment of septic myocardial injury.