右心室肥厚（right ventricular hypertrophy, RVH）和右心室衰竭（right ventricular failure, RVF）是具有致命性的恶性心脏疾病，肺动脉高压（pulmonary arterial hypertension, PAH）是主要的致病因素。大量研究已经发现，Ca2＋处理重塑在RVH和RVF发展过程中起至关重要的作用。文章主要以心力衰竭（heart failure, HF）患者的两大主要死因（心脏泵血功能下降和恶性心律失常）为框架，从微观角度详细阐述了在RVH和RVF病理过程中Ca2＋的作用及Ca2＋稳态的变化，以期为临床诊断与治疗提供新的方向。
Right ventricular hypertrophy (RVH) and right ventricular failure (RVF) are fatal heart disease. Pulmonary arterial hypertension (PAH) is the main pathogenic factor. Numerous studies have found that Ca2＋ handling remodeling plays a vital role in the progression of RVH and RVF. Using the heart failure (HF)'s two major causes of death (attenuation of myocardial pump function and malignant arrhythmia) as a frame , this review summarizes the role of Ca2＋ and Ca2＋ homeostasis alteration in pathological process of RVH and RVF from the micro aspects aims to provide a new direction for clinical diagnosis and treatment.
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