国际麻醉学与复苏杂志   2022, Issue (3): 0-0
    
CRISPR/Cas9基因编辑技术在心血管疾病研究中的应用进展
吴超, 何淑芳1()
1.安徽医科大学第二附属医院
Research advances on clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9 gene editing in cardiovascular disease
 全文:
摘要：

成簇规律间隔的短回文重复序列及其相关蛋白9（clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9, CRISPR/Cas9）基因编辑技术是一种能够通过DNA剪接而治疗多种疾病的基因编辑系统。该技术具有灵活简单、高效的优势，更重要的是能够同时编辑多个基因。近年来已经广泛应用于各个领域，在心血管领域中也取得了极大的进步。文章综述了CRISPR/Cas9基因编辑技术在心血管疾病研究中的应用进展，总结和列举基于CRISPR/Cas9基因编辑技术在心血管疾病预防和治疗中的应用，为心血管疾病治疗开创新方法提供参考。
关键词： 成簇规律间隔的短回文重复序列及其相关蛋白9； 基因编辑； 心血管疾病； 基因
Abstract:

Clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9 (CRISPR/Cas9) gene editing technology is a gene‑editing system that can treat a variety of diseases by splicing DNA. The technique has the advantages of being flexible, simple, efficient and, more importantly, able to edit multiple genes simultaneously. CRISPR/Cas9 gene editing technology has been widely used in various fields in recent years, including great advances in the cardiovascular field. In this review, the application advances of CRISPR/Cas9 gene editing technology in cardiovascular disease research is summarized and the application of CRISPR/Cas9 gene editing technology in the prevention and treatment of cardiovascular disease is described and listed, so as to provide reference for creating new methods in the treatment of cardiovascular disease.
Key words: Clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9; Gene editing; Cardiovascular disease; Gene therapy