Objective To summarize the evidence concerning the prevention of perioperative hypothermia and apply into clinical practice, so as to improve the compliance of nursing staff to the application of evidence, and discuss the influence of evidence application on perioperative hypothermia in adult liver transplantation patients. Methods A total of 149 patients who underwent orthotopic liver transplantation in Changgung Hospital from January 2018 to November 2019 were selected as a control group, while 137 patients who underwent orthotopic liver transplantation Changgung Hospital from February to December 2020 were selected as an evidence‑based group. The control group implemented the traditional temperature protection mode: patients were kept warm with circulating water blanket during the operation, and the forced‑air warming blanket was added to keep warm when the temperature fell below 36℃. The evidence‑based group applied the best evidence for the prevention and treatment of perioperative hypothermia. The risk of hypothermia was assessed before surgery. The forced‑air warming blanket was used for pre‑warming and warming for the patient during surgery. When the temperature fell below 36℃, an infusion heating device was added for warming. Both groups were compared for the basal body temperature and the body temperature 30 min after anesthesia, 1 h after anesthesia, when the abdominal cavity was opened, at liver free stage, at new liver stage and after surgery. The knowledge of perioperative hypothermia and the implementation rate of the evidence‑based preventive measures of perioperative hypothermia were compared before and after application. Results In the questionnaire survey, the correct rate of the knowledge of evidenced‑based prevention and treatment of perioperative hypothermia before evidence application was 62%, which was lower than 90% after application (P<0.05). After evidence application, the implementation rate of nursing staff to standards 1, 2, 3, 7 was higher than those before evidence application (P<0.05), but there was no significant difference in the implementation rate of standards 4, 5, 6 between the two groups (P>0.05). The body temperature of the evidence‑based group was higher than that the control group at the liver free stage, new liver stage and the end of operation (P<0.05). There was no statistical difference between the two groups as to basal body temperature, and the temperatures 30 min after anesthesia, 1 h after anesthesia and when the abdominal cavity was opened (P>0.05). Conclusions The evidence‑based clinical transformation model can reduce the incidence of perioperative hypothermia in adult liver transplantation patients, standardize the behavior of nursing staff, and improve the quality of perioperative medical care and nursing care.