国际麻醉学与复苏杂志   2022, Issue (4): 0-0
    
罗哌卡因用于老年髋部骨折患者椎管内麻醉 摆放体位前FICB的半数有效浓度
吴清华, 喻耀华, 柯品辉, 林良青1()
1.莆田市第一医院
The median effective concentration of ropivacaine for fascia iliaca compartment block before positioning for intrathecal anesthesia in elderly patients with hip fracture
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摘要:

目的 探讨罗哌卡因在老年髋部骨折患者椎管内麻醉摆放体位前行髂筋膜间隙阻滞(fascia iliaca compartment block, FICB)的半数有效浓度(median effective concentration, EC50)及其95%CI。 方法 选择2020年9月—2021年3月行髋部骨折手术的老年患者30例,年龄70~90岁,ASA分级Ⅱ、Ⅲ级,椎管内麻醉摆放体位前行超声引导下FICB。设定罗哌卡因容量为30 ml,初始浓度为0.3%,采用Dixon序贯法确定罗哌卡因的浓度,采用Probit概率法计算罗哌卡因的EC50及其95%CI。记录患者FICB前、FICB后15 min及摆放体位时的VAS疼痛评分及患者并发症(出血、血肿、局麻药中毒等)发生情况。 结果 FICB后15 min及摆放体位时患者VAS疼痛评分较FICB前降低(P<0.05)。所有患者均未出现出血、血肿及局麻药中毒等并发症。罗哌卡因用于老年髋部骨折患者椎管内麻醉摆放体位前FICB的EC50及其95%CI为0.14%(0.11%~0.16%)。 结论 罗哌卡因用于老年髋部骨折患者椎管内麻醉摆放体位前FICB的EC50及其95%CI为0.14%(0.11%~0.16%)。

关键词: 罗哌卡因; 髂筋膜间隙阻滞; 髋部骨折; 老年人
Abstract:

Objective To explore the median effective concentration (EC50) and 95% confidence interval (CI) of ropivacaine for fascia iliaca compartment block (FICB) before positioning for intrathecal anesthesia in elderly patients with hip fracture. Methods A total of 30 patients, aged 70‒90 years old, American Society of Anesthesiologists Ⅱ or Ⅲ, who were scheduled for hip fracture surgery from September 2020 to March 2021 were selected. FICB was performed under the guidance of ultrasound before positioning for intrathecal anesthesia. The pre‑set total volume of ropivacaine was 30 ml, with an initial concentration of 0.3%. The Dixon sequential method was used to determine the concentration of ropivacaine. The EC50 of ropivacaine and its 95%CI were calculated according to Probit analysis. The Visual Analogue Scale (VAS) scores were recorded before FICB, 15 min after FICB, and at positioning. The incidences of complications (bleeding, hematoma and local anesthetic intoxication) were recorded. Results The VAS scores 15 min after FICB and at positioning decreased, compared with those before FICB (P<0.05). There were no complications including bleeding, hematoma and local anesthetic intoxication. The EC50 of ropivacaine and its 95%CI for ultrasound‑guided FICB before positioning for intrathecal anesthesia in elderly patients with hip fracture was 0.14% (0.11%‒0.16%). Conclusions The EC50 of ropivacaine and its 95%CI is 0.14% (0.11%‒0.16%) for ultrasound‑guided FICB before positioning for intrathecal anesthesia in elderly patients with hip fracture.

Key words: Ropivacaine; Fascia iliaca compartment block; Hip fracture; Aged