Trigeminocardiac reflex (TCR) is a well‑recognized brainstem reflex that represents an interaction between the brain and the heart. TCR has mainly been reported as an intraoperative phenomenon causing cardiovascular changes during neurosurgical procedures. The main mechanism was attributed to autonomic tone's alteration. The current review provides brief updated analysis of these reflexes' features, with special focus on how the autonomic nervous system interacts with cardiovascular function and the role of TCR in myocardial injury.