As an important nucleus of the reward circuit in the midbrain, it plays an important role in the regulation of reward, addiction and withdrawal. In recent years, with the development of neuroimaging, optogenetics, chemogenetics and other technologies, more and more studies have found that the nucleus accumbens also plays an important role in the pain regulation, but its potential molecular and circuit mechanisms remain unclear. In this paper, we systematically review the role of the nucleus accumbens involved in the pain‑sensing regulation, and its possible mechanisms and perspectives on the molecular basis and neural circuits, which will provide new ideas and directions for pain treatment