Objective To observe the effects of different administration methods of urapidil on controlled hypotension during deep brain stimulation (DBS). Methods A total of 179 patients with Parkinson disease (PD) who underwent DBS were retrospectively included. Urapidil was used for controlled hypotension during the operation. The patients were divided into two groups: an urapidil continuous pumping group (group C, n=92) and a multiple intravenous infusion group (group C, n=87). Group C lowered mean artery pressure (MAP) to the target value (80% of the patient's basal MAP), before continuous infusion of urapidil at 5‒25 mg/h. Group D lowered MAP to the target and then intravenously administered with multiple doses according to MAP fluctuations. Their fluctuation range of MAP, heart rate and pulse oxygen saturation (SpO2) were recorded during controlled hypotension period (every 5 min within 1 h after MAP dropped to the target value). At the same time, the incidence of perioperative complications (including abnormal blood pressure increase, hypotension, air embolism, and intracranial hemorrhage) and the total dose of urapidil in the two groups were recorded during controlled hypotension period. Results After dropping to the target MAP, the fluctuation range of T1‒T10 MAP in group C was smaller than that in group D (P<0.05), and there was no significant difference in the fluctuation range of T11 and T12 MAP between the two groups (P>0.05). There was no significant difference in heart rate and SpO2 between the two groups during controlled hypotension period (P>0.05). The incidences of abnormal increases in perioperative blood pressure and hypotension in group C were lower than those in group D (P<0.05); there was no significant difference in the incidences of air embolism and intracranial hemorrhage between the two groups (P>0.05). During controlled hypotension period, the total dose of urapidil in group C was lower than that in group D (P<0.05). Conclusions For PD patients undergoing DBS, compared with multiple intravenous infusion of urapidil, continuous pumping of urapidil for controlled hypotension can result in more stable MAP, abnormally increased blood pressure and a low hypotension incidence, with a small total dose of urapidil.