【Abstract】 In the early stage of sepsis, excessive migration of neutrophils and enhanced autophagy activity lead to systemic inflammation. In the later stage, neutrophil migration and autophagy activity decrease, leading to immunosuppression. For sepsis, any immune mechanism link is indispensable. The clinical intervention of sepsis immunosuppressive state currently targets one or several immune targets. This article reviewed the immune mechanism of neutrophils' specific biological behaviors, such as delayed apoptosis, dysregulated migration and chemotaxis, and release of extracellular traps, to change the body from a systemic inflammatory response state to an immunosuppressive state during sepsis. This review intends to discuss the recent research advances on neutrophils in the pathogenesis of sepsis and provide reference for improving potent immunosuppression and immunoenhancing therapy in the late stage of sepsis.