Relapsing polychondritis (RP) is an autoimmune disease that may develop narrowing of the airway, lung infection, and increased secretion. This paper reported the perioperative management of a patient with RP undergoing radical surgery for lung cancer. The patient was diagnosed with lung adenocarcinoma with a lung infection, and RP was admitted due to a cough and chest tightness. The patient will be performed thoracoscopic radical resection of the right lower lobe carcinoma. Infection was controlled before surgery, and the left double‑lumen endotracheal catheter was intubated under general anesthesia during surgery. Since SpO2 was challenging to maintain, the surgery was completed under intermittent double‑lung ventilation. After the surgery, the tracheal tube was removed successfully. Then this patient was discharged from the hospital. Later, this patient was readmitted due to a lung infection. This case suggests that anesthesiologists should pay attention to perioperative airway management in patients with RP.