Objective To explore the clinical efficacy of percutaneous trigeminal radiofrequency thermocoagulation (PRT) and percutaneous balloon compression (PBC) in the treatment of concomitant continuous pain (CCP) in patients with trigeminal neuralgia (TN). Methods A total of 60 TN patients with CCP in trigeminal nerve branch 2 and (or) 3, who were treated in Department of Pain, the Affiliated Hospital of Xuzhou Medical University from September 2019 to February 2021 were enrolled and their clinical data were retrospectively analyzed. According to the treatment method, they were divided into two groups (n=30): a PRT group and a PBC group. Their pain and therapeutic effectiveness were evaluated by the Numerical Rating Scale (NRS) and Barrow Neurological Institute (BNI). The two groups were compared for NRS before operation (T0), immediately after postoperation (T1), one week after operation (T2), one month after operation (T3), three months after operation (T4), six months after operation (T5) and twelve months after operation (T6) and effective rate at T1‒T6. Their incidence of adverse reaction at T3 and the recurrence rate at T6 were compared. Results Compared with those at T0, NRS decreased at T1‒T6 in the two groups (P<0.05); and the PRT group showed higher NRS than the PBC group at T4‒T6 (P<0.05). The therapeutic effectiveness was better in the PBC group than in the PRT group at T5 and T6 (P<0.05). There was no statistical difference in the overall incidence of adverse reactions, such as severe numbness, decreased chewing power, salivation, and cold sores at T3 between the two groups (P>0.05). The pain recurrence rate was higher in the PRT group than the PBC group at T6 (P<0.05). Conclusions Both PRT and PBC can effectively treat TN patient with CCP. The pain recurrence rate was lower in the PBC group than the PRC group within twelve months after surgery. Compared with PRT, PBC is more effective in the treatment of CCP in TN patients.