目前已有证据表明，一些潜在的睡眠相关标记物与围手术期睡眠障碍的发生存在密切联系，可能对围手术期睡眠障碍的预测及诊断提供有价值的参考。文章综述睡眠相关标记物，如食欲素（orexin）系统、Homer1a蛋白、代谢型谷氨酸受体5（metabotropic glutamate receptor 5，mGluR5）调节蛋白、黑色素聚集激素（melanin‑concentrating hormone, MCH）系统、β淀粉样蛋白（amyloid β‑protein, Aβ）、Tau蛋白、突触结合蛋白（synaptotagmin, SYT）等，在预测围手术期睡眠障碍中的潜在价值，旨在为完善围手术期睡眠障碍的预测及诊断提供新的侧重点。
Some evidence indicates that some potential sleep‑related markers are closely related to perioperative sleep disorder, which may provide a valuable reference for its prediction and diagnosis. This review summarizes the potential value of these sleep‑related markers in the prediction of perioperative sleep disorder, such as orexin system, Homer1a protein, metabotropic glutamate receptor 5 (mGluR5) regulatory protein, melanin‑concentrating hormone (MCH) system, amyloid β‑protein (Aβ), Tau protein, synaptotagmin (SYT), and aims to provide new ideas for perfecting the prediction and diagnosis of perioperative sleep disorder.
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