Myocardial injury after non‑cardiac surgery (MINS) is the leading cause of death in patients after non‑cardiac surgery, which is closely related to postoperative cardiovascular complications and prognosis. Early monitoring and diagnosis of MIMS are of great clinical significance. This review introduces the definition, hazards, diagnostic basis, and existing monitoring methods of MINS. From the perspective of blood markers, the limitations of blood markers commonly used to monitor MINS are pointed out. The review summarizes the progress of novel blood markers of myocardial injury in recent years and illustrates the feasibility of their detection. For the early warning stratification, perioperative monitoring, and prognosis judgment of MINS, the combination of different blood markers may provide new ideas and references for the early monitoring of MINS. Novel blood markers for early monitoring of the occurrence of MIMS will offer more guidance value for reducing cardiovascular complications and mortality after non‑cardiac surgery.