Neuropathic pain (NP) is a common chronic pain in clinical practice, with a character of high incidence and refractory to treatment, which seriously affects the quality of patients' life. Its pathogenesis and therapeutic targets have always been the focus and difficulty of medical research. Sodium leak channel non‑selective protein (NALCN) is a kind of voltage‑independent, non‑selective, and non‑inactivating cation channel, which plays an important role in the generation of NP. The review summarizes recent study achievements on the structure and function of NALCN and variations mechanism to the NALCN involving in NP, including central sensitization, peripheral sensitization, regulation of the pain‑inducing effects of substance P (SP), and cyclic adenylic acid (cAMP)/protein kinase A (PKA) signaling pathway, in order to provide a new direction for neuropathic pain study and treatment.