Objective To explore the risk factors of deep brain stimulation (DBS) for postoperative delirium (POD) in patients with Parkinson's disease (PD). Methods PD patients who underwent selective DBS from October 2020 to May 2022 were prospectively selected and their preoperative data, intraoperative data, postoperative data and the incidence of POD were collected. According to the presence of postoperative delirium, the patients were divided into two groups: a delirium group (n=52) and a non‑delirium group (n=155). Then, both groups were compared for these data and logistic regression analysis was used to detect the risk factors for POD. Results A total of 207 patients were included into the study, among which 52 (25.1%) presented POD. Compared with the non‑delirium group, the delirium group showed increases in age, modified Hoehn‑Yahr (H‑Y) stage before surgery, and significantly Numerical Rating Scale (NRS) score on postoperative day 1 (all P<0.05). Multivariate logistic regression analysis indicated that age [adjusted odd ratio (OR) 1.09 [95% confidence interval (CI) 1.03, 1.16], P=0.002], modified H‑Y stage before surgery [adjusted OR 2.67 (95%CI 1.42, 5.00), P=0.002], and NRS score on postoperative day 1 [adjusted OR 1.44 (95%CI 1.22, 1.70), P<0.001] were the independent risk factors of DBS for POD. Conclusions The incidence of POD after DBS in PD is 25.1%. Age, modified H‑Y stage before surgery, and NRS score on postoperative day 1 are the independent risk factors for POD.