Abstract: Mesencephalic astrocyte‑derived neurotrophic factor (MANF) is an evolutionarily conserved neurotrophic factor. A large number of studies have shown that MANF plays an important role in cerebral ischemia‑reperfusion injury (CIRI). By participating in endoplasmic reticulum stress (ERS), inhibiting the inflammatory response and cell apoptosis, it alleviates CIRI. This article reviews the function of MANF, its effect, and its possible mechanism in CIRI, to provide a new direction for further exploring the prevention and treatment measures of CIRI.
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