Post‑dural puncture headache (PDPH) is a common complication after epidural anesthesia, which refers to the low cranial pressure headache caused by the puncture of the dura puncture. In the past, epidural blood patch (EBP) was often used for treatment, but due to its potential complications, the acceptance rate of patients was not high. In recent years, studies have proved that a new, simple, and minimally invasive operation‑‑sphenopalatine ganglion (SPG) block can effectively relieve PDPH. This review summarizes the anatomy, development history, mechanism, and operation of SPG block in PDPH treatment to provide a reference for SPG block treatment of PDPH application.