国际麻醉学与复苏杂志   2023, Issue (12): 0-0
    
围手术期液体管理与急性肾损伤研究进展
秦窈窈, 张鼎新, 郑兰, 张玮玮1()
1.山西医科大学麻醉学院
Research progress on perioperative fluid management and acute kidney injury
 全文:
摘要:

急性肾损伤(acute kidney injury,AKI)是围手术期常见的并发症,不仅表现为肾功能下降,还会增加术后并发症的发生风险,延长住院时间。液体治疗是围手术期预防和治疗AKI的关键。补液过多或过少都有可能导致或加重AKI。生理盐水的超生理氯化物含量和羟乙基淀粉(hydroxyethyl starch, HES)都有可能增加AKI的发生风险。白蛋白在AKI防治方面并没有显示出明显的益处。文章结合最新的临床研究,对AKI的定义、危险因素及围手术期不同液体治疗方式和液体种类对AKI的影响进行综述,旨在及时识别AKI高危患者和探索最佳的液体治疗方案,以改善手术患者预后。

关键词: 急性肾损伤; 补液疗法; 围手术期
Abstract:

Acute kidney injury (AKI) is a common complication during the perioperative period, which is characterized by not only declined kidney function, but also increased risks of postoperative complications, leading to prolonged length of hospitalization stays. Fluid therapy is crucial for the prevention and treatment of AKI during the perioperative period. Either excessive or insufficient fluid supplementation may potentially cause or exacerbate AKI. Both the supraphysiological chloride content in normal saline and hydroxyethyl starch (HES) can potentially increase the risk of AKI. Albumin has not demonstrated significant benefits in the prevention or treatment of AKI. Based on the latest clinical research, this article reviews the definition and risk factors of AKI, as well as the effect of various perioperative fluid management strategies and fluid types on AKI. The objective is to promptly identify patients with a high risk of AKI and to explore the optimal fluid therapy strategies, in order to enhance postoperative patient outcomes.

Key words: Acute kidney injury; Fluid therapy; Perioperative period