Abstract: Objective To determine the median effective dose (ED50) and 95% effective dose (ED95) of remimazolam besylate for sedation in pediatric patients during general anesthesia induction. Methods Child patients, aged 3‒12 years old, who were scheduled for surgery under total intravenous anesthesia were selected. The first patient was given intravenously remimazolam at 0.2 mg/kg. The modified Dixon's up⁃and⁃down method was used, where the dose of remimazolam for the next patient was determined on the basis of the unconsciousness in the previous child patient. Then, ED50 and ED95 of remimazolam besylate, and their corresponding 95% confidence interval (CI) were calculated by Probit regression and bootstrapping analysis. The time for sedation success, as well as the incidences of hypotension, bradycardia, hypoxemia, hiccup, injection pain during anesthesia induction were recorded. Results When remimazolam besylate was used for general anesthesia induction in pediatric patients, their ED50 and ED95 and their corresponding 95%CI for sedation success was 0.405 (0.312‒0.738) mg/kg and 0.673 (0.503‒0.954) mg/kg, and the time for sedation success was (76±11) s. There was 1 case (2.5%) of bradycardia and 6 cases of hiccup (15%) during anesthesia induction. No cases of hypoxemia, hiccup, injection pain were reported. Conclusions During general anesthesia induction in pediatric patients without other medications except remimazolam besylate, the ED50 for sedation success was 0.407 mg/kg, which is higher than that in adults.
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