双孔钾通道是新发现的钾通道超家族的一员，它被认为是吸入麻醉药敏感性钾通道的分子基础。吸入麻醉药作用于神经系统双孔钾通道部分亚型的某些位点，使该通道开放,而产生超极化电流。利用基因敲除动物模型进一步证实了双孔钾通道是吸入麻醉药作用的新靶点。
Two-pore-domain potassium channels (K2P channels), a new member of K+ channels superfamily, are deemed as molecular basis of inhalational-anesthetics- sensitive K+ channels. Ionically, Inhalational anesthetics could act on some sites of subunits of K2P channels and then open the channels and generate hyperpolarization current. It is further verified that some subunits of K2P channels are targets of inhalational anesthetics action in the gene knockout animal models.
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