Background Stress-related mucosal damage (SRMD)is a very common complication during the perioperative period, and it plays a great role in the initiation and progression of multiple organ dysfynction syndrome （MODS）. Objective This review summarized the mechanisms of electro-acupuncture in prophylaxis of stress-related mucosal damage. Content Electroacupuncture has a protective effect on stress gastric mucosal injury, which may be by reducing gastric acid secretion, increasing gastric mucus layer and mucosal thickness, inhibited reactive oxygen species （ROS） production and intracellular Ca2+ overload and reduce HPA axis activity and regulation of body ET-1/NO and COX-2/PGE2 endogenous levels achieved. Trend The mechanism of SRMD is very complex, and the protective effect of electroacupuncture on stress gastric mucosal injury is not unique to one single reason, maybe the combination of some mechanism.