脑缺血/再灌注损伤的机制十分复杂，其中近年来研究较多的NMDA受体（N-methyl-D-aspartate receptor, NMDAR）介导的兴奋毒性假说在临床上受到了严峻的挑战，已经开始关注海人藻酸受体(Kainate receptor, KAR)在脑缺血/再灌注损伤中的作用。现主要对脑缺血/再灌注损伤中KAR及其下游信号通路作用的研究 作一综述，为进一步研究KAR及临床防治脑缺血/再灌注损伤提供理论依据。
The mechanisms in cerebral ischemia and reperfusion injury are complicated. The hypothesis on exitotoxicity mediated by NMDA receptor faces several challenges. And recent studies have focused on the kainate receptor which mediates cerebral ischemia and reperfusion. This article reviews the recent progress in Kainate receptor and downstream signaling pathways in cerebral ischemical reperfusion injury. These theories may provide basis for the further investigate of kainate receptor and clinical practice.
Cited
)
